| Gene Information | |
|---|---|
| Gene Name | RNF112 |
| Organism | Homo sapiens (Human) |
| Gene Length | 631 |
| Protein Names | RING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Zinc finger protein 179) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000128482 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9ULX5 |
| Gene Card | RNF112 |
| Uniprot ID | Q9ULX5 |
| Pfam | PF02263; PF00097 |
| In ASD | no |
| Allosteric Prediction | no (-0.561647112) |
| Ortholog in Animals | Alpaca_ RNF112 ( ortholog_one2one ) Dog_ RNF112 ( ortholog_one2one ) GuineaPig_ RNF112 ( ortholog_one2one ) Macaque_ RNF112 ( ortholog_one2one ) Mouse_ Rnf112 ( ortholog_one2one ) Pig_ RNF112 ( ortholog_one2one ) Rat_ Rnf112 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATL1, GBP5, ATL2, GBP7, ATL3, GBP2, GBP6, GBP1, GBP4, GBP3 |
| Tissue | cerebral.cortex, cerebellum |
| Tissue Specificity | Predominantly expressed in brain (PubMed:10574464). Decreased expression in glioma brain tumors as compared to normal brains (at protein level) (PubMed:28684796). {ECO:0000269|PubMed:10574464, ECO:0000269|PubMed:28684796}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000250|UniProtKB:Q96DY5}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q96DY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasm {ECO:0000250|UniProtKB:Q96DY5}. Nucleus {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q96DY5}. Endosome {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q96DY5}. Postsynaptic density {ECO:0000250|UniProtKB:Q96DY5}. Perikaryon {ECO:0000250|UniProtKB:Q96DY5}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q96DY5}. Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas. {ECO:0000250|UniProtKB:Q96DY5}. |
| Mouse PG classification | NA |
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