| Gene Information | |
|---|---|
| Gene Name | RNF11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 154 |
| Protein Names | RING finger protein 11 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000123091 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y3C5 |
| Gene Card | RNF11 |
| Uniprot ID | Q9Y3C5 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.755265578) |
| Ortholog in Animals | Alpaca_ RNF11 ( ortholog_one2one ) Dog_ RNF11 ( ortholog_one2one ) GuineaPig_ RNF11 ( ortholog_one2one ) Mouse_ Rnf11 ( ortholog_one2one ) Pig_ RNF11 ( ortholog_one2one ) Rat_ Rnf11l1 ( ortholog_one2many ) Rat_ Rnf11l2 ( ortholog_one2many ) Rabbit_ RNF11 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ZNRF1, ZNRF2 |
| Tissue | NA |
| Tissue Specificity | Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites. Overexpressed in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in several tumor cell lines. {ECO:0000269|PubMed:14559117, ECO:0000269|PubMed:14562029, ECO:0000269|PubMed:17917589}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12077069 |
| Subcellular location [CC] | Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. {ECO:0000269|PubMed:16123141}. |
| Mouse PG classification | NA |
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