| Gene Information | |
|---|---|
| Gene Name | RNASE7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 156 |
| Protein Names | Ribonuclease 7 (RNase 7) (EC 3.1.27.-) (Skin-derived antimicrobial protein 2) (SAP-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 18 ( ENSG00000165799 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9H1E1 |
| Gene Card | RNASE7 |
| Uniprot ID | Q9H1E1 |
| Pfam | PF00074 |
| In ASD | no |
| Allosteric Prediction | no (-1.409060802) |
| Ortholog in Animals | Alpaca_ RNASE7 ( ortholog_one2one ) Macaque_ RNASE7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNASE8, RNASE10, RNASE9, RNASE6, RNASE2, RNASE3, RNASE1, RNASE11, ANG, RNASE4, RNASE12, RNASE13 |
| Tissue | esophagus |
| Tissue Specificity | Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level) (PubMed:25075772). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut (PubMed:12244054). Expressed in liver, kidney, skeletal muscle and heart (PubMed:12527768). {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768, ECO:0000269|PubMed:25075772}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2HKY (NMR - ) |
| DBSNP | rs1263872 rs1243469 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:25075772}. Note=Detected in urine. {ECO:0000269|PubMed:25075772}. |
| Mouse PG classification | NA |
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