| Gene Information | |
|---|---|
| Gene Name | RNASE6PL |
| Organism | Homo sapiens (Human) |
| Gene Length | 256 |
| Protein Names | Ribonuclease T2 (EC 4.6.1.19) (Ribonuclease 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O00584 |
| Gene Card | RNASET2 |
| Uniprot ID | O00584 |
| Pfam | PF00445 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain. {ECO:0000269|PubMed:19525954}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3T0O (X-ray 1.59A ) |
| DBSNP | rs121918137 rs11159 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15809705, ECO:0000269|PubMed:16620762}. Lysosome lumen {ECO:0000269|PubMed:16620762}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:16620762}. Mitochondrion intermembrane space {ECO:0000269|PubMed:28730546, ECO:0000269|PubMed:30184494, ECO:0000269|PubMed:30385512}. Note=Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction. {ECO:0000269|PubMed:16620762}. |
| Mouse PG classification | NA |
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