| Gene Information | |
|---|---|
| Gene Name | RNASE5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 147 |
| Protein Names | Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P03950 |
| Gene Card | ANG |
| Uniprot ID | P03950 |
| Pfam | PF00074 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. {ECO:0000269|PubMed:17886298, ECO:0000269|PubMed:2440105}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1A4Y (X-ray 2.00A ) 1ANG (X-ray 2.40A ) 1AWZ (NMR - ) 1B1E (X-ray 2.00A ) 1B1I (X-ray 1.80A ) 1B1J (X-ray 2.00A ) 1GV7 (X-ray 2.10A ) 1H0D (X-ray 2.00A ) 1H52 (X-ray 2.00A ) 1H53 (X-ray 2.00A ) 1HBY (X-ray 2.00A ) 1K58 (X-ray 2.70A ) 1K59 (X-ray 1.80A ) 1K5A (X-ray 2.33A ) 1K5B (X-ray 1.80A ) 1UN3 (X-ray 1.70A ) 1UN4 (X-ray 2.10A ) 1UN5 (X-ray 2.60A ) 2ANG (X-ray 2.00A ) 4AHD (X-ray 2.47A ) 4AHE (X-ray 2.08A ) 4AHF (X-ray 2.12A ) 4AHG (X-ray 2.45A ) 4AHH (X-ray 2.50A ) 4AHI (X-ray 2.80A ) 4AHJ (X-ray 2.03A ) 4AHK (X-ray 1.97A ) 4AHL (X-ray 2.05A ) 4AHM (X-ray 1.96A ) 4AHN (X-ray 2.98A ) 4AOH (X-ray 1.04A ) 4B36 (X-ray 1.76A ) 5EOP (X-ray 1.35A ) 5EPZ (X-ray 1.85A ) 5EQO (X-ray 2.40A ) 5M9A (X-ray 1.95A ) 5M9C (X-ray 2.05A ) 5M9G (X-ray 2.28A ) 5M9J (X-ray 1.90A ) 5M9M (X-ray 1.65A ) 5M9P (X-ray 1.80A ) 5M9Q (X-ray 1.35A ) 5M9R (X-ray 1.44A ) 5M9S (X-ray 1.85A ) 5M9T (X-ray 2.20A ) 5M9V (X-ray 1.70A ) 7NPM (X-ray 1.86A ) 7PNJ (X-ray 3.10A ) 7PNP (X-ray 1.80A ) 7PNR (X-ray 1.60A ) |
| DBSNP | rs121909535 rs1032422334 rs121909537 rs121909536 rs1440927797 rs121909542 rs121909538 rs121909539 rs121909540 rs121909541 rs17560 rs121909543 rs121909544 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q3TMQ6}. Secreted {ECO:0000250|UniProtKB:P10152}. Nucleus {ECO:0000269|PubMed:12051708, ECO:0000269|PubMed:25372031, ECO:0000269|PubMed:8127865}. Nucleus, nucleolus {ECO:0000269|PubMed:7945327}. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708). {ECO:0000269|PubMed:12051708}. |
| Mouse PG classification | NA |
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