| Gene Information | |
|---|---|
| Gene Name | RN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1374 |
| Protein Names | Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NRR4 |
| Gene Card | DROSHA |
| Uniprot ID | Q9NRR4 |
| Pfam | PF00035; PF14622; PF00636 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10948199}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002202(Rat);0.035294(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KHX (NMR - ) 2NA2 (NMR - ) 5B16 (X-ray 3.20A ) 6LXD (EM 3.90A ) 6LXE (EM 4.20A ) 6V5B (EM 3.70A ) 6V5C (EM 4.40A ) |
| DBSNP | rs35342496 rs55656741 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:22118463}. Nucleus, nucleolus {ECO:0000269|PubMed:10948199}. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:22118463}. |
| Mouse PG classification | NA |
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