| Gene Information | |
|---|---|
| Gene Name | RLN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 185 |
| Protein Names | Prorelaxin H2 [Cleaved into: Relaxin B chain; Relaxin A chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000107014 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P04090 |
| Gene Card | RLN2 |
| Uniprot ID | P04090 |
| Pfam | PF00049 |
| In ASD | no |
| Allosteric Prediction | yes (0.639444543) |
| Ortholog in Animals | Alpaca_ RLN2 ( ortholog_one2one ) Dog_ RLN2 ( ortholog_one2many ) Macaque_ RLN2 ( ortholog_one2one ) Mouse_ Rln1 ( ortholog_one2many ) Rat_ Rln1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | RLN1, INSL4, INSL6 |
| Tissue | ovary |
| Tissue Specificity | Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary. {ECO:0000269|PubMed:6548702, ECO:0000269|PubMed:8735594}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MV1 (NMR - ) 6RLX (X-ray 1.50A ) |
| DBSNP | rs2020050 rs618066 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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