| Gene Information | |
|---|---|
| Gene Name | DMTN |
| Organism | Homo sapiens (Human) |
| Gene Length | 405 |
| Protein Names | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000158856 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q08495 |
| Gene Card | DMTN |
| Uniprot ID | Q08495 |
| Pfam | PF16182; PF02209 |
| In ASD | no |
| Allosteric Prediction | no (-1.000267979) |
| Ortholog in Animals | Alpaca_ DMTN ( ortholog_one2one ) Dog_ DMTN ( ortholog_one2one ) GuineaPig_ DMTN ( ortholog_one2one ) Macaque_ DMTN ( ortholog_one2one ) Mouse_ Dmtn ( ortholog_one2one ) Pig_ DMTN ( ortholog_one2one ) Rat_ Dmtn ( ortholog_one2one ) Rabbit_ DMTN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ABLIM2, ABLIM3, ABLIM1 |
| Tissue | NA |
| Tissue Specificity | Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney. {ECO:0000269|PubMed:23060452}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1QZP (NMR - ) 1ZV6 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton. Cell membrane. Membrane {ECO:0000250}. Endomembrane system. Cell projection {ECO:0000250}. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuole in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development. |
| Mouse PG classification | NA |
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