| Gene Information | |
|---|---|
| Gene Name | RKHD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 659 |
| Protein Names | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q5U5Q3 |
| Gene Card | MEX3C |
| Uniprot ID | Q5U5Q3 |
| Pfam | PF00013 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine. {ECO:0000269|PubMed:17267406, ECO:0000269|PubMed:22863774}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5WWW (X-ray 1.80A ) 5WWX (X-ray 2.00A ) 5WWZ (X-ray 2.50A ) 5ZI6 (X-ray 2.20A ) |
| DBSNP | rs12970605 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17267406}. Nucleus {ECO:0000269|PubMed:17267406}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation. |
| Mouse PG classification | NA |
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