| Gene Information | |
|---|---|
| Gene Name | RIT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 217 |
| Protein Names | GTP-binding protein Rit2 (EC 3.6.5.2) (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000152214 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99578 |
| Gene Card | RIT2 |
| Uniprot ID | Q99578 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.220611513) |
| Ortholog in Animals | Alpaca_ RIT2 ( ortholog_one2one ) Dog_ RIT2 ( ortholog_one2one ) GuineaPig_ RIT2 ( ortholog_one2one ) Macaque_ RIT2 ( ortholog_one2one ) Mouse_ Rit2 ( ortholog_one2one ) Rat_ Rit2 ( ortholog_one2one ) Rabbit_ RIT2 ( ortholog_one2one ) |
| Ohnologs | RIT1 |
| Paralogs | RRAS, RHEB, KRAS, DIRAS1, RRAS2, RAP2B, HRAS, RERG, RASL12, RRAD, RIT1, DIRAS2, ERAS, NKIRAS1, RALB, RASD2, GEM, DIRAS3, MRAS, RAP2A, RASD1, REM1, NKIRAS2, RALA, RAP1A, RASL11B, RAP1B, RASL10A, RASL11A, REM2, RERGL, RHEBL1, NRAS, RAP2C, RASL10B |
| Tissue | brain, cerebellum, cerebellar.hemisphere |
| Tissue Specificity | Neuron-specific. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12934100, ECO:0000269|PubMed:16122393}. Cell membrane {ECO:0000269|PubMed:16122393}. Note=Colocalizes with PLXNB3 at the plasma membrane (PubMed:16122393). {ECO:0000269|PubMed:16122393}. |
| Mouse PG classification | NA |
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