| Gene Information | |
|---|---|
| Gene Name | RIT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 894 |
| Protein Names | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000143622 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9C0K0 |
| Gene Card | BCL11B |
| Uniprot ID | Q9C0K0 |
| Pfam | PF00096 |
| In ASD | no |
| Allosteric Prediction | yes (0.085279816) |
| Ortholog in Animals | Alpaca_ RIT1 ( ortholog_one2one ) Dog_ RIT1 ( ortholog_one2one ) GuineaPig_ RIT1 ( ortholog_one2one ) Macaque_ RIT1 ( ortholog_one2one ) Mouse_ Rit1 ( ortholog_one2one ) Pig_ RIT1 ( ortholog_one2one ) Rat_ Rit1 ( ortholog_one2one ) Rabbit_ RIT1 ( ortholog_one2one ) |
| Ohnologs | RIT2 |
| Paralogs | RRAS, RHEB, KRAS, DIRAS1, RRAS2, RAP2B, HRAS, RERG, RASL12, RRAD, DIRAS2, ERAS, NKIRAS1, RALB, RASD2, GEM, DIRAS3, MRAS, RAP2A, RASD1, REM1, NKIRAS2, RALA, RAP1A, RASL11B, RAP1B, RASL10A, RASL11A, REM2, RERGL, RIT2, RHEBL1, NRAS, RAP2C, RASL10B |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs749837100 rs750610248 rs888230251 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. |
| Mouse PG classification | NA |
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