| Gene Information | |
|---|---|
| Gene Name | RIP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 518 |
| Protein Names | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y572 |
| Gene Card | RIPK3 |
| Uniprot ID | Q9Y572 |
| Pfam | PF00069; PF12721 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. {ECO:0000269|PubMed:15896315}.; [Isoform 3]: Expression is significantly increased in colon and lung cancers. {ECO:0000269|PubMed:15896315}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5V7Z (NMR - ) 5ZCK (X-ray 1.27A ) 7DA4 (EM 4.24A ) 7DAC (NMR - ) 7MON (X-ray 2.23A ) 7MX3 (X-ray 3.23A ) |
| DBSNP | rs7153640 rs34106261 rs3212254 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:22265413}. Nucleus {ECO:0000250|UniProtKB:Q9QZL0}. Note=Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection. {ECO:0000250|UniProtKB:Q9QZL0}. |
| Mouse PG classification | NA |
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