| Gene Information | |
|---|---|
| Gene Name | RIP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 540 |
| Protein Names | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O43353 |
| Gene Card | RIPK2 |
| Uniprot ID | O43353 |
| Pfam | PF00619; PF07714 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node. {ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002323(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2N7Z (NMR - ) 2N83 (NMR - ) 4C8B (X-ray 2.75A ) 5AR2 (X-ray 2.44A ) 5AR3 (X-ray 3.23A ) 5AR4 (X-ray 2.70A ) 5AR5 (X-ray 2.66A ) 5AR7 (X-ray 2.71A ) 5AR8 (X-ray 2.79A ) 5J79 (X-ray 2.69A ) 5J7B (X-ray 2.53A ) 5NG0 (X-ray 2.00A ) 5NG2 (X-ray 2.80A ) 5NG3 (X-ray 2.60A ) 5W5J (X-ray 2.85A ) 5W5O (X-ray 2.89A ) 5YRN (EM 4.10A ) 6ES0 (X-ray 2.38A ) 6FU5 (X-ray 3.26A ) 6GFJ (X-ray 3.30A ) 6GGS (EM 3.94A ) 6HMX (X-ray 2.53A ) 6RN8 (X-ray 2.69A ) 6RNA (X-ray 2.62A ) 6S1F (X-ray 3.11A ) 6SZE (X-ray 2.94A ) 6SZJ (X-ray 2.53A ) 6UL8 (X-ray 2.68A ) 7OBS (X-ray 1.80A ) 7OBT (X-ray 2.30A ) |
| DBSNP | rs2230801 rs35004667 rs35395048 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21887730}. Endoplasmic reticulum {ECO:0000269|PubMed:28656966}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |