| Gene Information | |
|---|---|
| Gene Name | RIOX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 465 |
| Protein Names | Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.-) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000170854 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8IUF8 |
| Gene Card | RIOX2 |
| Uniprot ID | Q8IUF8 |
| Pfam | PF08007; PF20514 |
| In ASD | no |
| Allosteric Prediction | no (-0.761599486) |
| Ortholog in Animals | Alpaca_ RIOX2 ( ortholog_one2one ) Dog_ RIOX2 ( ortholog_one2one ) GuineaPig_ RIOX2 ( ortholog_one2one ) Macaque_ RIOX2 ( ortholog_one2one ) Mouse_ Riox2 ( ortholog_one2one ) Pig_ RIOX2 ( ortholog_one2one ) Rat_ Riox2 ( ortholog_one2many ) Rabbit_ RIOX2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RIOX1 |
| Tissue | NA |
| Tissue Specificity | Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. {ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:19502796}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XDV (X-ray 2.57A ) 4BU2 (X-ray 2.78A ) 4BXF (X-ray 2.05A ) |
| DBSNP | rs35391656 rs56183666 rs2172257 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}. Nucleus, nucleolus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}. |
| Mouse PG classification | NA |
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