| Gene Information | |
|---|---|
| Gene Name | P4HTM |
| Organism | Homo sapiens (Human) |
| Gene Length | 502 |
| Protein Names | Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) |
| Target Name | transmembrane prolyl 4-hydroxylase |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000178467 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NXG6 |
| Gene Card | P4HTM |
| Uniprot ID | Q9NXG6 |
| Pfam | PF13640; PF13499 |
| In ASD | no |
| Allosteric Prediction | no (-0.203093848) |
| Ortholog in Animals | Alpaca_ P4HTM ( ortholog_one2one ) Dog_ P4HTM ( ortholog_one2one ) GuineaPig_ P4HTM ( ortholog_one2one ) Macaque_ P4HTM ( ortholog_one2one ) Mouse_ P4htm ( ortholog_one2one ) Pig_ P4HTM ( ortholog_one2one ) Rat_ P4htm ( ortholog_one2one ) Rabbit_ P4HTM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | P4HA2, P4HA3, P4HA1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6TP5 (X-ray 2.25A ) |
| DBSNP | rs1576606484 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}; Single-pass type II membrane protein {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}. |
| Mouse PG classification | NA |
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