| Gene Information | |
|---|---|
| Gene Name | WNK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2297 |
| Protein Names | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000165238 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y3S1 |
| Gene Card | WNK2 |
| Uniprot ID | Q9Y3S1 |
| Pfam | PF12202; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.49051434) |
| Ortholog in Animals | Alpaca_ WNK2 ( ortholog_one2one ) Dog_ WNK2 ( ortholog_one2one ) GuineaPig_ WNK2 ( ortholog_one2one ) Macaque_ WNK2 ( ortholog_one2one ) Mouse_ Wnk2 ( ortholog_one2one ) Pig_ WNK2 ( ortholog_one2one ) Rat_ Wnk2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NRBP1, NRBP2, WNK4, WNK1, WNK3, DSTYK |
| Tissue | NA |
| Tissue Specificity | Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon. {ECO:0000269|PubMed:11571656, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:21733846}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6ELM (X-ray 1.14A ) 6FBK (X-ray 1.74A ) |
| DBSNP | rs10761203 rs10114908 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598}. Cell membrane {ECO:0000269|PubMed:18593598}. |
| Mouse PG classification | NA |
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