| Gene Information | |
|---|---|
| Gene Name | RIMS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1411 |
| Protein Names | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000176406 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UQ26 |
| Gene Card | RIMS2 |
| Uniprot ID | Q9UQ26 |
| Pfam | PF00168; PF02318; PF17820 |
| In ASD | no |
| Allosteric Prediction | no (-0.216341109) |
| Ortholog in Animals | Alpaca_ RIMS2 ( ortholog_one2one ) Dog_ RIMS2 ( ortholog_one2one ) GuineaPig_ RIMS2 ( ortholog_one2one ) Macaque_ RIMS2 ( ortholog_one2one ) Mouse_ Rims2 ( ortholog_one2one ) Pig_ RIMS2 ( ortholog_one2one ) Rat_ Rims2 ( ortholog_one2one ) Rabbit_ RIMS2 ( ortholog_one2one ) |
| Ohnologs | RIMS1 |
| Paralogs | RIMS3, RIMS4, RIMS1, NANOGNB |
| Tissue | adrenal.gland, brain |
| Tissue Specificity | Widely expressed (PubMed:32470375). Expressed in melanocytes (PubMed:23999003). In fetal tissues, predominantly expressed in the brain (PubMed:32470375). In the retina, expressed in the outer plexiform layer (at protein level) (PubMed:32470375). In the cerebellum, expressed in Purkinje cells (at protein level) (PubMed:32470375). In the pancreas, expressed in Langerhans islets (at protein level) (PubMed:32470375). {ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:32470375}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1V27 (NMR - ) 1WFG (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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