| Gene Information | |
|---|---|
| Gene Name | PITRM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1037 |
| Protein Names | Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000107959 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q5JRX3 |
| Gene Card | PITRM1 |
| Uniprot ID | Q5JRX3 |
| Pfam | PF08367; PF00675; PF05193 |
| In ASD | no |
| Allosteric Prediction | no (-0.214306344) |
| Ortholog in Animals | Alpaca_ PITRM1 ( ortholog_one2one ) Dog_ PITRM1 ( ortholog_one2one ) GuineaPig_ PITRM1 ( ortholog_one2one ) Macaque_ PITRM1 ( ortholog_one2one ) Mouse_ Pitrm1 ( ortholog_one2one ) Pig_ PITRM1 ( ortholog_one2one ) Rat_ Pitrm1 ( ortholog_one2one ) Rabbit_ PITRM1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PMPCA, UQCRC1, NRDC, UQCRC2, PMPCB, IDE |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta. {ECO:0000269|PubMed:10360838}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4L3T (X-ray 2.03A ) 4NGE (X-ray 2.70A ) 4RPU (X-ray 2.27A ) 6XOS (EM 3.70A ) 6XOT (EM 3.90A ) 6XOU (EM 4.00A ) 6XOV (EM 3.30A ) 6XOW (EM 4.60A ) |
| DBSNP | rs11818724 rs9423502 rs3814596 rs1249144069 rs4242746 rs3182535 rs3765101 rs12248937 rs2388556 rs34837384 rs187308159 rs2279219 rs17849904 rs2279218 rs6901 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:26697887}. Mitochondrion matrix {ECO:0000269|PubMed:16849325, ECO:0000269|PubMed:19196155, ECO:0000269|PubMed:21621546}. |
| Mouse PG classification | NA |
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