| Gene Information | |
|---|---|
| Gene Name | RILP |
| Organism | Homo sapiens (Human) |
| Gene Length | 401 |
| Protein Names | Rab-interacting lysosomal protein |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000167705 ) 3 ( ENSG00000274145 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96NA2 |
| Gene Card | RILP |
| Uniprot ID | Q96NA2 |
| Pfam | PF09744; PF11461 |
| In ASD | no |
| Allosteric Prediction | no (-0.433501016) |
| Ortholog in Animals | Alpaca_ RILP ( ortholog_one2one ) Dog_ RILP ( ortholog_one2one ) GuineaPig_ RILP ( ortholog_one2one ) Mouse_ Rilp ( ortholog_one2one ) Pig_ RILP ( ortholog_one2one ) Rat_ Rilp ( ortholog_one2one ) Rabbit_ RILP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RILPL1, DZIP1L, DZIP1, RILPL2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain. {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11520070, ECO:0000269|PubMed:14668488}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YHN (X-ray 3.00A ) |
| DBSNP | rs9909321 rs34982553 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476}. Lysosome membrane {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476}. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes. {ECO:0000269|PubMed:12944476}. |
| Mouse PG classification | NA |
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