Gene Information
Gene NameRIL
OrganismHomo sapiens (Human)
Gene Length330
Protein NamesPDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP50479
Gene CardPDLIM4
Uniprot IDP50479
PfamPF15936; PF00412; PF00595
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue Specificity[Isoform 2]: Found in brain. {ECO:0000269|PubMed:9573374}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2EEG  (NMR  -  )  2V1W  (X-ray  1.90A  )  4Q2O  (X-ray  2.10A  ) 
DBSNP rs17851430  rs1050805  rs175218  rs4877 
Subcellular location [CC][Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21636573}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:21636573}. Cytoplasm {ECO:0000269|PubMed:21636573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell projection, lamellipodium {ECO:0000269|PubMed:10826496}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P36202}. Early endosome membrane {ECO:0000250|UniProtKB:P36202};
Peripheral membrane protein {ECO:0000250|UniProtKB:P36202};
Cytoplasmic side {ECO:0000250|UniProtKB:P36202}. Recycling endosome membrane {ECO:0000250|UniProtKB:P36202};
Peripheral membrane protein {ECO:0000250|UniProtKB:P36202};
Cytoplasmic side {ECO:0000250|UniProtKB:P36202}. Synapse, synaptosome {ECO:0000250|UniProtKB:P36202}. Note=Localizes to actin stress fibers in nonmuscle cells. Colocalizes with GRIA1 in early endosomes. Enriched in numerous but not all spine-like structures along dendritic branches. Colocalizes with actin and enriched at sites containing larger amounts of actin and alpha-actinin. Targeted efficiently to spines via its PDZ domain-mediated interaction with the alpha-actinin/actin cytoskeletal complex. Localizes to synaptosomes in brain (By similarity). Colocalizes with F-actin (PubMed:10826496). Colocalizes with TRIP6 at cell-cell contacts and lamellipodia (PubMed:10826496). In the cytoplasm, displays a fibrillar pattern with characteristic thick fibers and occasional clusters. Colocalizes with the actin stress fibers. Oxidative stress induces redistribution from cytoskeleton to cytosol (PubMed:21636573). Colocalizes with SRC at the perinuclear region, but not at focal adhesions (PubMed:19307596). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.;
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:21636573}. Note=Stains more diffusely in the cytoplasm with thin fibers forming a dense mesh-like pattern. {ECO:0000269|PubMed:21636573}.
Mouse PG classificationNA
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