| Gene Information | |
|---|---|
| Gene Name | RIC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 369 |
| Protein Names | Protein RIC-3 (Resistant to inhibitor of cholinesterase 3) |
| Target Name | protein ric-3 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000166405 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z5B4 |
| Gene Card | RIC3 |
| Uniprot ID | Q7Z5B4 |
| Pfam | PF15361 |
| In ASD | no |
| Allosteric Prediction | yes (0.331209477) |
| Ortholog in Animals | Alpaca_ RIC3 ( ortholog_one2one ) Dog_ RIC3 ( ortholog_one2one ) GuineaPig_ RIC3 ( ortholog_one2one ) Macaque_ RIC3 ( ortholog_one2one ) Mouse_ Ric3 ( ortholog_one2one ) Pig_ RIC3 ( ortholog_one2one ) Rat_ Ric3 ( ortholog_one2one ) Rabbit_ RIC3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain. {ECO:0000269|PubMed:12821669, ECO:0000269|PubMed:17640815, ECO:0000269|PubMed:18691158}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17855498 rs55990541 |
| Subcellular location [CC] | [Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. |
| Mouse PG classification | NA |
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