| Gene Information | |
|---|---|
| Gene Name | CORIN |
| Organism | Homo sapiens (Human) |
| Gene Length | 1042 |
| Protein Names | Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000145244 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y5Q5 |
| Gene Card | CORIN |
| Uniprot ID | Q9Y5Q5 |
| Pfam | PF01392; PF00057; PF15494; PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.409544265) |
| Ortholog in Animals | Alpaca_ CORIN ( ortholog_one2one ) Dog_ CORIN ( ortholog_one2one ) GuineaPig_ CORIN ( ortholog_one2one ) Macaque_ CORIN ( ortholog_one2one ) Mouse_ Corin ( ortholog_one2one ) Pig_ CORIN ( ortholog_one2one ) Rat_ Corin ( ortholog_one2one ) Rabbit_ CORIN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | heart, left.atrium, left.ventricle, mitral.valve, pulmonary.valve |
| Tissue Specificity | Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level). {ECO:0000269|PubMed:10329693, ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:22437503}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2289433 rs387906894 rs13105608 rs387906895 rs11934749 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:21518754}; Single-pass type II membrane protein {ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:21518754}. Note=May easily detached from the endothelial cell membrane.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1.; [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted. Note=Soluble form produced following cleavage by ADAM10.; [Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage.; [Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage. |
| Mouse PG classification | NA |
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