| Gene Information | |
|---|---|
| Gene Name | RHOT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 618 |
| Protein Names | Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000126858 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IXI2 |
| Gene Card | RHOT1 |
| Uniprot ID | Q8IXI2 |
| Pfam | PF08355; PF08356; PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.150506174) |
| Ortholog in Animals | Alpaca_ RHOT1 ( ortholog_one2one ) Dog_ RHOT1 ( ortholog_one2one ) GuineaPig_ RHOT1 ( ortholog_one2one ) Macaque_ RHOT1 ( ortholog_one2one ) Mouse_ Rhot1 ( ortholog_one2one ) Pig_ RHOT1 ( ortholog_one2one ) Rat_ Rnf135 ( ortholog_one2one ) Rabbit_ RHOT1 ( ortholog_one2one ) |
| Ohnologs | RHOT2 |
| Paralogs | RND1, CDC42, RHOBTB3, RHOT2, RAC1, RAC3, RHOJ, RHOA, RHOC, RHOB, RHOV, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RHOU, RAC2, RHOBTB1, RHOH |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269|PubMed:12482879}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5KSO (X-ray 2.25A ) 5KSP (X-ray 2.16A ) 5KSY (X-ray 2.48A ) 5KSZ (X-ray 2.50A ) 5KTY (X-ray 2.52A ) 5KU1 (X-ray 2.50A ) 6D71 (X-ray 1.72A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria. |
| Mouse PG classification | NA |
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