| Gene Information | |
|---|---|
| Gene Name | PIK3CA |
| Organism | Homo sapiens (Human) |
| Gene Length | 1068 |
| Protein Names | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) |
| Target Name | pi3-kinase alpha |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000121879 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P42336 |
| Gene Card | PIK3CA |
| Uniprot ID | P42336 |
| Pfam | PF00454; PF00792; PF02192; PF00794; PF00613 |
| In ASD | yes |
| Allosteric Prediction | yes (1.74805748) |
| Ortholog in Animals | Alpaca_ PIK3CA ( ortholog_one2one ) Dog_ PIK3CA ( ortholog_one2one ) GuineaPig_ PIK3CA ( ortholog_one2one ) Macaque_ PIK3CA ( ortholog_one2one ) Mouse_ Pik3ca ( ortholog_one2one ) Pig_ PIK3CA ( ortholog_one2one ) Rat_ Pik3ca ( ortholog_one2one ) Rabbit_ PIK3CA ( ortholog_one2one ) |
| Ohnologs | PIK3CG, PIK3CB, PIK3CD |
| Paralogs | PIK3CG, PIK3CB, PIK3C2B, PIK3C2A, PI4KB, PI4KA, PIK3C2G, PIK3C3, PIK3CD |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2ENQ (NMR - ) 2RD0 (X-ray 3.05A ) 3HHM (X-ray 2.80A ) 3HIZ (X-ray 3.30A ) 3ZIM (X-ray 2.85A ) 4JPS (X-ray 2.20A ) 4L1B (X-ray 2.59A ) 4L23 (X-ray 2.50A ) 4L2Y (X-ray 2.80A ) 4OVU (X-ray 2.96A ) 4OVV (X-ray 3.50A ) 4TUU (X-ray 2.64A ) 4TV3 (X-ray 2.85A ) 4WAF (X-ray 2.39A ) 4YKN (X-ray 2.90A ) 4ZOP (X-ray 2.62A ) 5DXH (X-ray 3.00A ) 5DXT (X-ray 2.25A ) 5FI4 (X-ray 2.50A ) 5ITD (X-ray 3.02A ) 5SW8 (X-ray 3.30A ) 5SWG (X-ray 3.11A ) 5SWO (X-ray 3.50A ) 5SWP (X-ray 3.41A ) 5SWR (X-ray 3.31A ) 5SWT (X-ray 3.49A ) 5SX8 (X-ray 3.47A ) 5SX9 (X-ray 3.52A ) 5SXA (X-ray 3.35A ) 5SXB (X-ray 3.30A ) 5SXC (X-ray 3.55A ) 5SXD (X-ray 3.50A ) 5SXE (X-ray 3.51A ) 5SXF (X-ray 3.46A ) 5SXI (X-ray 3.40A ) 5SXJ (X-ray 3.42A ) 5SXK (X-ray 3.55A ) 5UBR (X-ray 2.40A ) 5UK8 (X-ray 2.50A ) 5UKJ (X-ray 2.80A ) 5UL1 (X-ray 3.00A ) 5XGH (X-ray 2.97A ) 5XGI (X-ray 2.56A ) 5XGJ (X-ray 2.97A ) 6GVF (X-ray 2.50A ) 6GVG (X-ray 3.00A ) 6GVH (X-ray 2.74A ) 6GVI (X-ray 2.90A ) 6NCT (X-ray 3.35A ) 6OAC (X-ray 3.15A ) 6PYS (X-ray 2.19A ) 6VO7 (X-ray 2.31A ) 7JIU (X-ray 2.12A ) 7K6M (X-ray 2.41A ) 7K6N (X-ray 2.77A ) 7K6O (X-ray 2.74A ) 7K71 (X-ray 2.90A ) 7L1B (X-ray 2.04A ) 7L1C (X-ray 1.96A ) 7L1D (X-ray 3.11A ) 7MLK (X-ray 2.91A ) 7MYN (EM 2.79A ) 7MYO (EM 2.92A ) 7PG5 (X-ray 2.20A ) 7PG6 (X-ray 2.50A ) 7R9V (X-ray 2.69A ) 7R9Y (X-ray 2.85A ) 7RRG (X-ray 2.12A ) 7TZ7 (X-ray 2.41A ) |
| DBSNP | rs772110575 rs1051399 rs1057519929 rs1560137208 rs121913287 rs1057519930 rs863225460 rs587777790 rs587777791 rs587777792 rs1051407 rs587777793 rs1576935161 rs1064793732 rs397514565 rs587777794 rs2230461 rs121913272 rs1057519925 rs121913273 rs121913273 rs1057519927 rs121913274 rs121913274 rs104886003 rs121913286 rs121913286 rs397517201 rs397517201 rs867262025 rs587776932 rs121913288 rs397517202 rs1242945375 rs121913283 rs121913279 rs121913279 rs121913281 rs121913277 rs1560150596 |
| Subcellular location [CC] | NA |
| Mouse PG classification | LPG |
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