| Gene Information | |
|---|---|
| Gene Name | MAP3K9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1104 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) |
| Target Name | mitogen-activated protein kinase kinase kinase 9 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000006432 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P80192 |
| Gene Card | MAP3K9 |
| Uniprot ID | P80192 |
| Pfam | PF00069; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.426082664) |
| Ortholog in Animals | Alpaca_ MAP3K9 ( ortholog_one2one ) Dog_ MAP3K9 ( ortholog_one2one ) GuineaPig_ MAP3K9 ( ortholog_one2one ) Macaque_ MAP3K9 ( ortholog_one2one ) Mouse_ Map3k9 ( ortholog_one2one ) Pig_ MAP3K9 ( ortholog_one2one ) Rat_ Map3k9 ( ortholog_one2one ) Rabbit_ MAP3K9 ( ortholog_one2one ) |
| Ohnologs | MAP3K10, MAP3K21, MAP3K11 |
| Paralogs | LIMK2, RIPK1, LRRK2, TNNI3K, TESK2, KSR2, MAP3K10, RIPK2, MOS, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3 |
| Tissue | cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. {ECO:0000269|PubMed:8477742}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3DTC (X-ray 2.60A ) 4UY9 (X-ray 2.81A ) |
| DBSNP | rs773256562 rs56196343 rs34322726 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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