Gene Information
Gene NameTRPM4
OrganismHomo sapiens (Human)
Gene Length1214
Protein NamesTransient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)
Target Namelong transient receptor potential channel 4
Target TypeClinical trial target
Gene Age680 ( ENSG00000130529 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ8TD43
Gene CardTRPM4
Uniprot IDQ8TD43
PfamPF00520; PF18139
In ASDno
Allosteric Predictionyes (0.476596453)
Ortholog in AnimalsAlpaca_ TRPM4 ( ortholog_one2many )
Dog_ TRPM4 ( ortholog_one2one )
GuineaPig_ TRPM4 ( ortholog_one2one )
Macaque_ TRPM4 ( ortholog_one2one )
Mouse_ Trpm4 ( ortholog_one2one )
Pig_ TRPM4 ( ortholog_one2one )
Rat_ Trpm4 ( ortholog_one2one )
OhnologsTRPM2, TRPM5, TRPM7, TRPM1
ParalogsTRPM3, TRPM5, TRPM1, TRPM7, TRPM8, TRPM2, TRPM6
TissueNA
Tissue SpecificityWidely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. Expressed in keratocytes (PubMed:30528822). {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:16777713, ECO:0000269|PubMed:19726882, ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:30528822}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5WP6  (EM  3.80A  )  6BQR  (EM  3.20A  )  6BQV  (EM  3.10A  )  6BWI  (EM  3.70A  ) 
DBSNP rs267607142  rs113984787  rs144781529  rs172146854  rs387907216  rs146564314  rs172147855  rs201907325  rs56355369  rs172149856  rs172150857  rs200038418  rs172155862  rs172151858  rs172152859  rs1278993777  rs1369949906  rs150391806 
Subcellular location [CC][Isoform 1]: Cell membrane {ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:19945433, ECO:0000269|PubMed:29211723};
Multi-pass membrane protein {ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581}. Endoplasmic reticulum {ECO:0000269|PubMed:19945433}. Golgi apparatus {ECO:0000269|PubMed:19945433}.;
[Isoform 2]: Cell membrane {ECO:0000269|PubMed:11535825}. Endoplasmic reticulum. Golgi apparatus.
Mouse PG classificationHPG
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