| Gene Information | |
|---|---|
| Gene Name | RGS9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 674 |
| Protein Names | Regulator of G-protein signaling 9 (RGS9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000108370 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O75916 |
| Gene Card | RGS9 |
| Uniprot ID | O75916 |
| Pfam | PF00610; PF00631; PF00615; PF18148 |
| In ASD | no |
| Allosteric Prediction | yes (0.187524994) |
| Ortholog in Animals | Alpaca_ RGS9 ( ortholog_one2one ) Dog_ RGS9 ( ortholog_one2one ) GuineaPig_ RGS9 ( ortholog_one2one ) Macaque_ RGS9 ( ortholog_one2one ) Mouse_ Rgs9 ( ortholog_one2one ) Pig_ RGS9 ( ortholog_one2one ) Rat_ Rgs9 ( ortholog_one2one ) Rabbit_ RGS9 ( ortholog_one2one ) |
| Ohnologs | RGS11, RGS7 |
| Paralogs | RGS18, RGS5, RGS3, RGS20, RGS2, RGSL1, RGS12, RGS21, AXIN1, RGS1, RGS11, RGS17, RGS7, RGS14, AXIN2, RGS22, RGS4, RGS6, RGS13, RGS19, RGS8, RGS16, RGS10 |
| Tissue | caudate.nucleus, pineal.gland, putamen, nucleus.accumbens |
| Tissue Specificity | Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors). |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.054545(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs12452285 rs121908449 |
| Subcellular location [CC] | [Isoform 3]: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via its interaction with RGS9BP. {ECO:0000250}. |
| Mouse PG classification | NA |
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