| Gene Information | |
|---|---|
| Gene Name | RGS8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 180 |
| Protein Names | Regulator of G-protein signaling 8 (RGS8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000135824 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P57771 |
| Gene Card | RGS8 |
| Uniprot ID | P57771 |
| Pfam | PF00615 |
| In ASD | no |
| Allosteric Prediction | no (-0.778458103) |
| Ortholog in Animals | Alpaca_ RGS8 ( ortholog_one2one ) Dog_ RGS8 ( ortholog_one2one ) GuineaPig_ RGS8 ( ortholog_one2one ) Macaque_ RGS8 ( ortholog_one2one ) Mouse_ Rgs8 ( ortholog_one2one ) Pig_ RGS8 ( ortholog_one2one ) Rat_ Rgs8 ( ortholog_one2one ) Rabbit_ RGS8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RGS16, RGS18, RGS5, RGS3, RGS20, RGS2, RGSL1, RGS12, RGS21, AXIN1, RGS1, RGS11, RGS17, RGS7, RGS14, AXIN2, RGS22, RGS4, RGS6, RGS9, RGS13, RGS19, RGS10 |
| Tissue | caudate.nucleus, nucleus.accumbens, putamen |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IHD (X-ray 1.70A ) 2ODE (X-ray 1.90A ) 5DO9 (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Perikaryon {ECO:0000250|UniProtKB:P49804}. Cell projection, dendrite {ECO:0000250|UniProtKB:P49804}. Nucleus {ECO:0000250|UniProtKB:P49804}. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000250|UniProtKB:P49804}. |
| Mouse PG classification | NA |
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