| Gene Information | |
|---|---|
| Gene Name | HLAF |
| Organism | Homo sapiens (Human) |
| Gene Length | 346 |
| Protein Names | HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P30511 |
| Gene Card | HLA-F |
| Uniprot ID | P30511 |
| Pfam | PF07654; PF00129 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in resting B cells (at protein level). Expressed in secondary lymphoid organs rich in B and T cells such as the tonsils, spleen, and thymus (at protein level) (PubMed:10605026, PubMed:11169396). Expressed in the endothelial cells of the tonsils (PubMed:11169396). Expressed on activated lymphoid cells including B cells, NK cells, CD4+ T cells and memory T cells (at protein level) (PubMed:27455421, PubMed:20865824). Expressed in motor neurons of spinal cord (PubMed:26928464). {ECO:0000269|PubMed:10605026, ECO:0000269|PubMed:11169396, ECO:0000269|PubMed:20865824, ECO:0000269|PubMed:26928464, ECO:0000269|PubMed:27455421}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5IUE (X-ray 2.62A ) 5KNM (X-ray 3.30A ) |
| DBSNP | rs17875379 rs17875380 rs1736924 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16709803, ECO:0000269|PubMed:23851683, ECO:0000305|PubMed:27455421}; Single-pass type I membrane protein. Early endosome membrane {ECO:0000269|PubMed:23851683}. Lysosome membrane {ECO:0000269|PubMed:23851683}. Note=For cross-presentation transits from the cell surface through endosomal pathway to lysosomes, where the peptide is generated from internalized exogenous antigen. {ECO:0000269|PubMed:23851683}. |
| Mouse PG classification | NA |
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