Gene Information
Gene NameSNX18
OrganismHomo sapiens (Human)
Gene Length628
Protein NamesSorting nexin-18 (SH3 and PX domain-containing protein 3B)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000178996 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ96RF0
Gene CardSNX18
Uniprot IDQ96RF0
PfamPF10456; PF00787; PF14604
In ASDno
Allosteric Predictionyes (0.213702969)
Ortholog in AnimalsAlpaca_ SNX18 ( ortholog_one2one )
Dog_ SNX18 ( ortholog_one2one )
GuineaPig_ SNX18 ( ortholog_one2one )
Macaque_ SNX18 ( ortholog_one2one )
Mouse_ Snx18 ( ortholog_one2one )
Pig_ SNX18 ( ortholog_one2one )
Rat_ Snx18 ( ortholog_one2one )
Rabbit_ SNX18 ( ortholog_one2one )
OhnologsSNX33
ParalogsSNX5, SNX6, SNX2, SNX7, SNX33, SNX10, SNX4, SNX1, SNX11, SNX12, SNX3, SNX30, SNX8, SNX32, SNX9
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs2548612  rs13162502 
Subcellular location [CC]Endomembrane system {ECO:0000269|PubMed:22718350};
Peripheral membrane protein {ECO:0000269|PubMed:18411244};
Cytoplasmic side {ECO:0000269|PubMed:18411244}. Endosome membrane {ECO:0000269|PubMed:29437695};
Peripheral membrane protein {ECO:0000269|PubMed:18411244};
Cytoplasmic side {ECO:0000269|PubMed:18411244}. Recycling endosome membrane {ECO:0000269|PubMed:29437695};
Peripheral membrane protein {ECO:0000269|PubMed:18411244};
Cytoplasmic side {ECO:0000269|PubMed:18411244}. Cell membrane {ECO:0000269|PubMed:20427313};
Peripheral membrane protein {ECO:0000269|PubMed:18411244};
Cytoplasmic side {ECO:0000269|PubMed:18411244}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18411244};
Peripheral membrane protein {ECO:0000269|PubMed:18411244};
Cytoplasmic side {ECO:0000269|PubMed:18411244}. Note=Localized at sites of endocytosis at the cell membrane (PubMed:18411244). Detected on newly formed macropinosomes (PubMed:21048941). Partially colocalized with clathrin and dynamin at the cell membrane (PubMed:20427313). Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation (PubMed:18411244). {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941}.
Mouse PG classificationNA
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