| Gene Information | |
|---|---|
| Gene Name | RGS14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 566 |
| Protein Names | Regulator of G-protein signaling 14 (RGS14) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000169220 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O43566 |
| Gene Card | RGS14 |
| Uniprot ID | O43566 |
| Pfam | PF02188; PF02196; PF00615 |
| In ASD | yes |
| Allosteric Prediction | yes (0.510691226) |
| Ortholog in Animals | Alpaca_ RGS14 ( ortholog_one2one ) Dog_ RGS14 ( ortholog_one2one ) GuineaPig_ RGS14 ( ortholog_one2one ) Macaque_ RGS14 ( ortholog_one2one ) Mouse_ Rgs14 ( ortholog_one2one ) Pig_ RGS14 ( ortholog_one2one ) Rat_ Rgs14 ( ortholog_one2one ) Rabbit_ RGS14 ( ortholog_one2one ) |
| Ohnologs | RGS12 |
| Paralogs | RGS18, RGS5, RGS3, RGS20, RGS2, RGSL1, RGS12, RGS21, AXIN1, RGS1, RGS11, RGS17, RGS7, AXIN2, RGS22, RGS4, RGS6, RGS9, RGS13, RGS19, RGS8, RGS16, RGS10 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);0.133333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JNU (NMR - ) 2OM2 (X-ray 2.20A ) 2XNS (X-ray 3.41A ) 3ONW (X-ray 2.38A ) 3QI2 (X-ray 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:15917656}. Membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15917656}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel-shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Relocalizes to the nucleus in PML nuclear bodies in response to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons. Localizes to spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS. Colocalizes with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and membranes (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |