| Gene Information | |
|---|---|
| Gene Name | RGS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 209 |
| Protein Names | Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000090104 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q08116 |
| Gene Card | RGS1 |
| Uniprot ID | Q08116 |
| Pfam | PF00615 |
| In ASD | no |
| Allosteric Prediction | no (-0.285599468) |
| Ortholog in Animals | Alpaca_ RGS1 ( ortholog_one2one ) Dog_ RGS1 ( ortholog_one2one ) GuineaPig_ RGS1 ( ortholog_one2one ) Macaque_ RGS1 ( ortholog_one2one ) Mouse_ Rgs1 ( ortholog_one2one ) Pig_ RGS1 ( ortholog_one2one ) Rat_ Rgs1 ( ortholog_one2one ) Rabbit_ RGS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RGS18, RGS5, RGS3, RGS20, RGS2, RGSL1, RGS12, RGS21, AXIN1, RGS11, RGS17, RGS7, RGS14, AXIN2, RGS22, RGS4, RGS6, RGS9, RGS13, RGS19, RGS8, RGS16, RGS10 |
| Tissue | NA |
| Tissue Specificity | Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738). {ECO:0000269|PubMed:10480894, ECO:0000269|PubMed:8473738}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2BV1 (X-ray 2.00A ) 2GTP (X-ray 2.55A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10480894}; Peripheral membrane protein {ECO:0000269|PubMed:10480894}; Cytoplasmic side {ECO:0000269|PubMed:10480894}. Cytoplasm, cytosol {ECO:0000269|PubMed:10480894}. |
| Mouse PG classification | NA |
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