| Gene Information | |
|---|---|
| Gene Name | DNAJA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 397 |
| Protein Names | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000086061 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P31689 |
| Gene Card | DNAJA1 |
| Uniprot ID | P31689 |
| Pfam | PF00226; PF01556; PF00684 |
| In ASD | no |
| Allosteric Prediction | yes (0.096330142) |
| Ortholog in Animals | Alpaca_ DNAJA1 ( ortholog_one2one ) Dog_ DNAJA1 ( ortholog_one2one ) GuineaPig_ DNAJA1 ( ortholog_one2one ) Macaque_ DNAJA1 ( ortholog_one2one ) Mouse_ Dnaja1 ( ortholog_one2one ) Pig_ DNAJA1 ( ortholog_one2one ) Rat_ Dnaja1 ( ortholog_one2many ) Rabbit_ DNAJA1 ( ortholog_one2one ) |
| Ohnologs | DNAJA4 |
| Paralogs | DNAJA2, DNAJA4, DNAJA3 |
| Tissue | substantia.nigra |
| Tissue Specificity | Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver. {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:15595953}. |
| Pharmacological Animal Models | 0.012449(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2LO1 (NMR - ) 2M6Y (NMR - ) 6E8M (X-ray 1.61A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000305|PubMed:10816573}; Lipid-anchor {ECO:0000305|PubMed:10816573}. Cytoplasm {ECO:0000269|PubMed:10816573}. Microsome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10816573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10816573}. Mitochondrion {ECO:0000250}. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}. |
| Mouse PG classification | NA |
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