| Gene Information | |
|---|---|
| Gene Name | RETREG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 497 |
| Protein Names | Reticulophagy regulator 1 (Reticulophagy receptor 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 70 ( ENSG00000154153 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H6L5 |
| Gene Card | RETREG1 |
| Uniprot ID | Q9H6L5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.841445231) |
| Ortholog in Animals | Alpaca_ RETREG1 ( ortholog_one2one ) GuineaPig_ RETREG1 ( ortholog_one2one ) Macaque_ RETREG1 ( ortholog_one2one ) Mouse_ Retreg1 ( ortholog_one2one ) Pig_ RETREG1 ( ortholog_one2one ) Rabbit_ RETREG1 ( ortholog_one2one ) |
| Ohnologs | RETREG2 |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Overexpressed in esophageal squamous cell carcinoma (PubMed:17487424). {ECO:0000269|PubMed:17487424}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7BRQ (X-ray 1.40A ) 7FB5 (X-ray 2.84A ) |
| DBSNP | rs1579584286 rs34432513 |
| Subcellular location [CC] | Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q8VE91}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:26040720}; Multi-pass membrane protein {ECO:0000255}.; Endoplasmic reticulum membrane {ECO:0000269|PubMed:35239449}; Multi-pass membrane protein {ECO:0000255}. Note=(Microbial infection) Following SARS-CoV-2 infection, colocalizes with SARS-CoV-2 ORF3A protein at the endoplasmic reticulum. {ECO:0000269|PubMed:35239449}. |
| Mouse PG classification | NA |
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