| Gene Information | |
|---|---|
| Gene Name | REPS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 796 |
| Protein Names | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000135597 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96D71 |
| Gene Card | REPS1 |
| Uniprot ID | Q96D71 |
| Pfam | PF12763 |
| In ASD | no |
| Allosteric Prediction | yes (0.317258292) |
| Ortholog in Animals | Alpaca_ REPS1 ( ortholog_one2one ) GuineaPig_ REPS1 ( ortholog_one2one ) Macaque_ REPS1 ( ortholog_one2one ) Mouse_ Reps1 ( ortholog_one2one ) Pig_ REPS1 ( ortholog_one2one ) Rat_ Reps1 ( ortholog_one2one ) Rabbit_ REPS1 ( ortholog_one2one ) |
| Ohnologs | REPS2 |
| Paralogs | EPS15L1, REPS2, ITSN2, SRL, EPS15, ITSN1, EHD2, EHD4, EHD3, EHD1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in heart and testis. {ECO:0000269|PubMed:11750063}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.046811(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1554292444 rs201191394 |
| Subcellular location [CC] | Membrane, clathrin-coated pit {ECO:0000269|PubMed:20946875}. Note=Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits. |
| Mouse PG classification | NA |
| click here to return to the previous page | |