| Gene Information | |
|---|---|
| Gene Name | PLD4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 506 |
| Protein Names | 5'-3' exonuclease PLD4 (EC 3.1.16.1) (Choline phosphatase 4) (Phosphatidylcholine-hydrolyzing phospholipase D4) (Phospholipase D family member 4) (Phospholipase D4) (PLD 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000166428 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96BZ4 |
| Gene Card | PLD4 |
| Uniprot ID | Q96BZ4 |
| Pfam | PF13918 |
| In ASD | no |
| Allosteric Prediction | no (-0.078324351) |
| Ortholog in Animals | Alpaca_ PLD4 ( ortholog_one2one ) GuineaPig_ PLD4 ( ortholog_one2one ) Macaque_ PLD4 ( ortholog_one2one ) Mouse_ Pld4 ( ortholog_one2one ) Pig_ PLD4 ( ortholog_one2one ) Rat_ Pld4 ( ortholog_one2one ) |
| Ohnologs | PLD3 |
| Paralogs | PLD5, PLD3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs894037 rs2841280 rs3803295 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BG07}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BG07}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q8BG07}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BG07}. Nucleus {ECO:0000250|UniProtKB:Q8BG07}. Early endosome {ECO:0000250|UniProtKB:Q8BG07}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q8BG07}. Note=Activation of microglia induces translocation of PLD4 from the nucleus to the phagosomes. {ECO:0000250|UniProtKB:Q8BG07}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |