| Gene Information | |
|---|---|
| Gene Name | REM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 298 |
| Protein Names | GTP-binding protein REM 1 (GTPase-regulating endothelial cell sprouting) (Rad and Gem-like GTP-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000088320 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75628 |
| Gene Card | REM1 |
| Uniprot ID | O75628 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | yes (0.128905142) |
| Ortholog in Animals | Alpaca_ REM1 ( ortholog_one2one ) Alpaca_ REM1 ( ortholog_one2many ) Dog_ REM1 ( ortholog_one2one ) GuineaPig_ REM1 ( ortholog_one2one ) Macaque_ REM1 ( ortholog_one2one ) Mouse_ Rem1 ( ortholog_one2one ) Pig_ REM1 ( ortholog_one2one ) Rat_ Rem1 ( ortholog_one2one ) Rabbit_ REM1 ( ortholog_one2one ) |
| Ohnologs | REM2, GEM, RRAD |
| Paralogs | RRAS, RHEB, KRAS, DIRAS1, RRAS2, RAP2B, HRAS, RERG, RASL12, RRAD, RIT1, DIRAS2, ERAS, NKIRAS1, RALB, RASD2, GEM, DIRAS3, MRAS, RAP2A, RASD1, NKIRAS2, RALA, RAP1A, RASL11B, RAP1B, RASL10A, RASL11A, REM2, RERGL, RIT2, RHEBL1, NRAS, RAP2C, RASL10B |
| Tissue | NA |
| Tissue Specificity | Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2NZJ (X-ray 2.50A ) |
| DBSNP | rs1006459 rs59730832 rs2233829 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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