| Gene Information | |
|---|---|
| Gene Name | SPPL2C |
| Organism | Homo sapiens (Human) |
| Gene Length | 684 |
| Protein Names | Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 18 ( ENSG00000185294 ) 3 ( ENSG00000277106 ) 3 ( ENSG00000278194 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IUH8 |
| Gene Card | SPPL2C |
| Uniprot ID | Q8IUH8 |
| Pfam | PF04258 |
| In ASD | no |
| Allosteric Prediction | no (-0.990339888) |
| Ortholog in Animals | Alpaca_ SPPL2C ( ortholog_one2many ) Dog_ SPPL2C ( ortholog_one2one ) GuineaPig_ SPPL2C ( ortholog_one2one ) Macaque_ SPPL2C ( ortholog_one2one ) Mouse_ Sppl2c ( ortholog_one2one ) Pig_ SPPL2C ( ortholog_one2one ) Rat_ Sppl2c ( ortholog_one2one ) Rabbit_ SPPL2C ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SPPL2B, SPPL3, SPPL2A, HM13 |
| Tissue | testis |
| Tissue Specificity | Highly expressed in testis where it is primarily localised in spermatids (at protein level). {ECO:0000269|PubMed:32048434}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17763658 rs242944 rs12185233 rs12185268 rs12373123 rs12373139 rs17852270 rs12373142 rs16940694 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:30733280, ECO:0000269|PubMed:32048434}; Multi-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000269|PubMed:15385547, ECO:0000269|PubMed:16829952}. |
| Mouse PG classification | NA |
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