| Gene Information | |
|---|---|
| Gene Name | KCNK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 394 |
| Protein Names | Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1) |
| Target Name | potassium channel subfamily k member 3 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000171303 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O14649 |
| Gene Card | KCNK3 |
| Uniprot ID | O14649 |
| Pfam | PF07885 |
| In ASD | no |
| Allosteric Prediction | yes (1.11959863) |
| Ortholog in Animals | Alpaca_ KCNK3 ( ortholog_one2one ) Dog_ KCNK3 ( ortholog_one2one ) GuineaPig_ KCNK3 ( ortholog_one2one ) Macaque_ KCNK3 ( ortholog_one2one ) Mouse_ Kcnk3 ( ortholog_one2one ) Pig_ KCNK3 ( ortholog_one2one ) Rat_ Kcnk3 ( ortholog_one2one ) Rabbit_ KCNK3 ( ortholog_one2one ) |
| Ohnologs | KCNK15, KCNK9 |
| Paralogs | KCNK6, KCNK15, KCNK13, KCNK1, KCNK17, KCNK9, KCNK2, KCNK18, KCNK16, KCNK12, KCNK7, KCNK4, KCNK5, KCNK10 |
| Tissue | adrenal.gland |
| Tissue Specificity | Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6RV2 (X-ray 3.00A ) 6RV3 (X-ray 2.90A ) 6RV4 (X-ray 3.10A ) |
| DBSNP | rs1085307438 rs398123040 rs398123042 rs398123043 rs398123039 rs398123041 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23169818}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | LPG |
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