| Gene Information | |
|---|---|
| Gene Name | TTC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 440 |
| Protein Names | Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Protein Strap) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000136319 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8N0Z6 |
| Gene Card | TTC5 |
| Uniprot ID | Q8N0Z6 |
| Pfam | PF16669 |
| In ASD | no |
| Allosteric Prediction | no (-0.454685344) |
| Ortholog in Animals | Alpaca_ TTC5 ( ortholog_one2one ) Dog_ TTC5 ( ortholog_one2one ) GuineaPig_ TTC5 ( ortholog_one2one ) Macaque_ TTC5 ( ortholog_one2one ) Mouse_ Ttc5 ( ortholog_one2one ) Pig_ TTC5 ( ortholog_one2one ) Rat_ Ttc5 ( ortholog_one2one ) Rabbit_ TTC5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.019234(Mouse);0.001000(Rat);0.019231(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XVS (X-ray 1.80A ) 6T59 (EM 3.11A ) 7QWS (EM 3.40A ) |
| DBSNP | rs34675160 rs3742945 rs749799203 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q99LG4}. Cytoplasm {ECO:0000269|PubMed:31727855}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q99LG4}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q99LG4}. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. Nuclear localization may be necessary for DNA damage-dependent stabilization of the protein. {ECO:0000250|UniProtKB:Q99LG4}. |
| Mouse PG classification | NA |
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