| Gene Information | |
|---|---|
| Gene Name | CRLF3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 442 |
| Protein Names | Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000176390 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IUI8 |
| Gene Card | CRLF3 |
| Uniprot ID | Q8IUI8 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.529577919) |
| Ortholog in Animals | Alpaca_ CRLF3 ( ortholog_one2one ) Dog_ CRLF3 ( ortholog_one2one ) GuineaPig_ CRLF3 ( ortholog_one2one ) Mouse_ Crlf3 ( ortholog_one2one ) Pig_ CRLF3 ( ortholog_one2one ) Rat_ Crlf3 ( ortholog_one2one ) Rabbit_ CRLF3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATAD5 |
| Tissue | NA |
| Tissue Specificity | Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK). {ECO:0000269|PubMed:16865251, ECO:0000269|PubMed:19427400}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3764418 rs11867457 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19427400}. Note=The EGFP- and MYC-tagged protein has been shown to be cytoplasmic. {ECO:0000269|PubMed:19427400}. |
| Mouse PG classification | NA |
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