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Gene Information
Gene Name
HME1
Organism
Homo sapiens (Human)
Gene Length
248
Protein Names
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
P31947
Gene Card
SFN
Uniprot ID
P31947
Pfam
PF00244
In ASD
no
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.001642(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1YWT
(X-ray
2.40A
)
1YZ5
(X-ray
2.80A
)
3IQJ
(X-ray
1.15A
)
3IQU
(X-ray
1.05A
)
3IQV
(X-ray
1.20A
)
3LW1
(X-ray
1.28A
)
3MHR
(X-ray
1.15A
)
3O8I
(X-ray
2.00A
)
3P1N
(X-ray
1.40A
)
3P1O
(X-ray
1.90A
)
3P1P
(X-ray
1.95A
)
3P1Q
(X-ray
1.70A
)
3P1R
(X-ray
1.70A
)
3P1S
(X-ray
1.65A
)
3SMK
(X-ray
2.10A
)
3SML
(X-ray
1.90A
)
3SMM
(X-ray
2.00A
)
3SMN
(X-ray
2.00A
)
3SMO
(X-ray
1.80A
)
3SP5
(X-ray
1.80A
)
3SPR
(X-ray
1.99A
)
3T0L
(X-ray
1.60A
)
3T0M
(X-ray
1.62A
)
3U9X
(X-ray
1.80A
)
3UX0
(X-ray
1.75A
)
4DAT
(X-ray
1.40A
)
4DAU
(X-ray
2.00A
)
4DHM
(X-ray
1.70A
)
4DHN
(X-ray
1.80A
)
4DHO
(X-ray
1.70A
)
4DHP
(X-ray
1.75A
)
4DHQ
(X-ray
1.75A
)
4DHR
(X-ray
1.40A
)
4DHS
(X-ray
1.74A
)
4DHT
(X-ray
1.80A
)
4DHU
(X-ray
1.67A
)
4FL5
(X-ray
1.90A
)
4FR3
(X-ray
1.90A
)
4IEA
(X-ray
1.70A
)
4JC3
(X-ray
2.05A
)
4JDD
(X-ray
2.10A
)
4QLI
(X-ray
1.45A
)
4Y32
(X-ray
1.70A
)
4Y3B
(X-ray
1.80A
)
4Y5I
(X-ray
1.40A
)
5BTV
(X-ray
1.70A
)
5HF3
(X-ray
1.80A
)
5LTW
(X-ray
4.50A
)
5LU1
(X-ray
2.40A
)
5LU2
(X-ray
2.50A
)
5MHC
(X-ray
1.20A
)
5MOC
(X-ray
1.80A
)
5MXO
(X-ray
1.20A
)
5MY9
(X-ray
1.33A
)
5MYC
(X-ray
1.46A
)
5N5R
(X-ray
1.80A
)
5N5T
(X-ray
1.80A
)
5N5W
(X-ray
1.37A
)
5N75
(X-ray
1.80A
)
5OEG
(X-ray
3.15A
)
5OEH
(X-ray
2.35A
)
5OK9
(X-ray
2.35A
)
5OKF
(X-ray
3.20A
)
5OM0
(X-ray
3.20A
)
5OMA
(X-ray
3.90A
)
6FAU
(X-ray
1.25A
)
6FAV
(X-ray
1.40A
)
6FAW
(X-ray
1.40A
)
6FBB
(X-ray
1.30A
)
6FBW
(X-ray
1.45A
)
6FBY
(X-ray
1.50A
)
6FCP
(X-ray
1.45A
)
6FI4
(X-ray
2.00A
)
6FI5
(X-ray
1.70A
)
6G6X
(X-ray
1.13A
)
6G8I
(X-ray
1.60A
)
6G8J
(X-ray
1.47A
)
6G8K
(X-ray
1.25A
)
6G8L
(X-ray
1.37A
)
6G8P
(X-ray
1.90A
)
6G8Q
(X-ray
1.85A
)
6GHP
(X-ray
1.95A
)
6HHP
(X-ray
1.80A
)
6HKB
(X-ray
1.70A
)
6HKF
(X-ray
1.80A
)
6HMT
(X-ray
1.10A
)
6HMU
(X-ray
1.20A
)
6HN2
(X-ray
1.70A
)
6NV2
(X-ray
1.13A
)
6QDR
(X-ray
1.61A
)
6QDS
(X-ray
1.72A
)
6QDT
(X-ray
1.70A
)
6QDU
(X-ray
1.63A
)
6QHL
(X-ray
1.20A
)
6QHM
(X-ray
1.25A
)
6QIU
(X-ray
1.80A
)
6QZR
(X-ray
2.30A
)
6QZS
(X-ray
1.90A
)
6R5L
(X-ray
1.88A
)
6RHC
(X-ray
1.20A
)
6RJL
(X-ray
1.28A
)
6RJQ
(X-ray
1.89A
)
6RJZ
(X-ray
1.58A
)
6RK8
(X-ray
1.60A
)
6RKI
(X-ray
1.88A
)
6RKK
(X-ray
1.88A
)
6RKM
(X-ray
1.88A
)
6RL3
(X-ray
1.30A
)
6RL4
(X-ray
1.60A
)
6RL6
(X-ray
1.60A
)
6RM5
(X-ray
1.88A
)
6RM7
(X-ray
1.60A
)
6RP6
(X-ray
1.89A
)
6RWH
(X-ray
1.68A
)
6RWI
(X-ray
1.65A
)
6RWS
(X-ray
1.53A
)
6RWU
(X-ray
1.46A
)
6RX2
(X-ray
1.82A
)
6S39
(X-ray
1.88A
)
6S3C
(X-ray
2.00A
)
6S40
(X-ray
1.90A
)
6S9Q
(X-ray
1.69A
)
6SIN
(X-ray
1.64A
)
6SIO
(X-ray
1.60A
)
6SIP
(X-ray
1.60A
)
6SIQ
(X-ray
1.60A
)
6SLV
(X-ray
1.90A
)
6SLW
(X-ray
2.00A
)
6SLX
(X-ray
1.80A
)
6T5F
(X-ray
2.63A
)
6T5H
(X-ray
2.04A
)
6T80
(X-ray
2.99A
)
6TCH
(X-ray
1.80A
)
6TJM
(X-ray
1.85A
)
6TL3
(X-ray
2.46A
)
6TLF
(X-ray
2.90A
)
6TLG
(X-ray
2.40A
)
6TM7
(X-ray
3.00A
)
6TWZ
(X-ray
2.80A
)
6W0L
(X-ray
2.30A
)
6XWD
(X-ray
1.60A
)
6XXC
(X-ray
1.30A
)
6XY5
(X-ray
1.30A
)
6Y18
(X-ray
1.30A
)
6Y1D
(X-ray
1.38A
)
6Y1J
(X-ray
1.13A
)
6Y3M
(X-ray
1.50A
)
6Y3O
(X-ray
1.50A
)
6Y3R
(X-ray
1.50A
)
6Y3S
(X-ray
1.95A
)
6Y3V
(X-ray
1.50A
)
6Y3W
(X-ray
1.34A
)
6Y40
(X-ray
1.75A
)
6Y44
(X-ray
1.71A
)
6Y58
(X-ray
1.90A
)
6Y7T
(X-ray
2.50A
)
6Y8A
(X-ray
1.50A
)
6Y8B
(X-ray
1.54A
)
6Y8D
(X-ray
1.51A
)
6Y8E
(X-ray
1.42A
)
6YE9
(X-ray
1.80A
)
6YIA
(X-ray
1.30A
)
6YIB
(X-ray
1.70A
)
6YIC
(X-ray
1.60A
)
6YLU
(X-ray
1.88A
)
6YOW
(X-ray
1.23A
)
6YOX
(X-ray
2.05A
)
6YOY
(X-ray
1.80A
)
6YP2
(X-ray
1.80A
)
6YP3
(X-ray
1.80A
)
6YP8
(X-ray
1.80A
)
6YPL
(X-ray
1.80A
)
6YPY
(X-ray
1.40A
)
6YQ2
(X-ray
1.40A
)
6YR5
(X-ray
2.25A
)
6YR6
(X-ray
1.75A
)
6YR7
(X-ray
2.10A
)
6ZCJ
(X-ray
1.53A
)
6ZVB
(X-ray
2.51A
)
6ZVC
(X-ray
2.51A
)
6ZVD
(X-ray
2.50A
)
6ZVE
(X-ray
2.51A
)
7AEW
(X-ray
1.20A
)
7AOG
(X-ray
1.50A
)
7AXN
(X-ray
1.40A
)
7AYF
(X-ray
1.75A
)
7AZ1
(X-ray
1.15A
)
7AZ2
(X-ray
1.08A
)
7B13
(X-ray
1.37A
)
7B15
(X-ray
1.59A
)
7B9M
(X-ray
1.70A
)
7B9R
(X-ray
1.15A
)
7B9T
(X-ray
1.15A
)
7BA3
(X-ray
1.40A
)
7BA5
(X-ray
1.45A
)
7BA6
(X-ray
1.40A
)
7BA7
(X-ray
1.45A
)
7BA8
(X-ray
1.20A
)
7BA9
(X-ray
1.48A
)
7BAA
(X-ray
1.10A
)
7BAB
(X-ray
1.30A
)
7BDP
(X-ray
1.75A
)
7BDT
(X-ray
1.75A
)
7BDY
(X-ray
1.80A
)
7BFW
(X-ray
1.80A
)
7BG3
(X-ray
1.40A
)
7BGQ
(X-ray
1.75A
)
7BGR
(X-ray
1.80A
)
7BGV
(X-ray
1.68A
)
7BGW
(X-ray
1.90A
)
7BI3
(X-ray
1.20A
)
7BIQ
(X-ray
1.20A
)
7BIW
(X-ray
1.20A
)
7BIY
(X-ray
1.80A
)
7BJB
(X-ray
1.80A
)
7BJF
(X-ray
1.40A
)
7BJL
(X-ray
1.40A
)
7BJW
(X-ray
1.40A
)
7BKH
(X-ray
1.40A
)
7BM9
(X-ray
1.80A
)
7BMC
(X-ray
2.00A
)
7NFW
(X-ray
1.19A
)
7NIF
(X-ray
1.71A
)
7NIG
(X-ray
1.90A
)
7NIX
(X-ray
1.90A
)
7NIZ
(X-ray
1.48A
)
7NJ6
(X-ray
1.59A
)
7NJ8
(X-ray
1.80A
)
7NJ9
(X-ray
1.40A
)
7NJA
(X-ray
1.75A
)
7NJB
(X-ray
1.40A
)
7NK3
(X-ray
1.40A
)
7NK5
(X-ray
1.40A
)
7NLA
(X-ray
1.40A
)
7NLE
(X-ray
1.40A
)
7NM1
(X-ray
1.40A
)
7NM3
(X-ray
1.40A
)
7NM9
(X-ray
1.70A
)
7NMA
(X-ray
1.75A
)
7NMH
(X-ray
1.40A
)
7NMW
(X-ray
1.50A
)
7NMX
(X-ray
2.30A
)
7NN2
(X-ray
1.80A
)
7NND
(X-ray
1.40A
)
7NNE
(X-ray
1.96A
)
7NP2
(X-ray
1.27A
)
7NPB
(X-ray
1.37A
)
7NPG
(X-ray
1.37A
)
7NQP
(X-ray
1.24A
)
7NR7
(X-ray
1.40A
)
7NRK
(X-ray
1.75A
)
7NRL
(X-ray
1.80A
)
7NSV
(X-ray
1.33A
)
7NV4
(X-ray
1.20A
)
7NVI
(X-ray
1.20A
)
7NWS
(X-ray
1.20A
)
7NXS
(X-ray
1.20A
)
7NXT
(X-ray
1.20A
)
7NXW
(X-ray
1.20A
)
7NXY
(X-ray
1.20A
)
7NY4
(X-ray
1.40A
)
7NYE
(X-ray
1.40A
)
7NYF
(X-ray
1.40A
)
7NYG
(X-ray
1.40A
)
7NZ6
(X-ray
1.40A
)
7NZG
(X-ray
1.40A
)
7NZK
(X-ray
1.40A
)
7NZV
(X-ray
1.40A
)
7O07
(X-ray
1.20A
)
7O34
(X-ray
1.20A
)
7O3A
(X-ray
1.20A
)
7O3F
(X-ray
1.40A
)
7O3P
(X-ray
1.40A
)
7O3Q
(X-ray
1.80A
)
7O3R
(X-ray
1.80A
)
7O3S
(X-ray
2.00A
)
7O57
(X-ray
1.40A
)
7O59
(X-ray
1.20A
)
7O5A
(X-ray
1.80A
)
7O5C
(X-ray
1.80A
)
7O5D
(X-ray
1.80A
)
7O5F
(X-ray
1.80A
)
7O5G
(X-ray
1.80A
)
7O5O
(X-ray
1.80A
)
7O5P
(X-ray
1.80A
)
7O5S
(X-ray
1.80A
)
7O5U
(X-ray
1.80A
)
7O5X
(X-ray
1.80A
)
7O6F
(X-ray
2.00A
)
7O6G
(X-ray
1.80A
)
7O6I
(X-ray
1.80A
)
7O6J
(X-ray
1.40A
)
7O6K
(X-ray
1.40A
)
7O6M
(X-ray
1.40A
)
7O6O
(X-ray
1.40A
)
7OB5
(X-ray
1.80A
)
7OB8
(X-ray
1.80A
)
7OBC
(X-ray
1.90A
)
7OBD
(X-ray
2.00A
)
7OBG
(X-ray
1.80A
)
7OBH
(X-ray
2.00A
)
7OBK
(X-ray
1.80A
)
7OBL
(X-ray
1.80A
)
7OBS
(X-ray
1.80A
)
7OBT
(X-ray
2.30A
)
7OBX
(X-ray
1.80A
)
7OBY
(X-ray
2.10A
)
7OPW
(X-ray
1.81A
)
7OQ7
(X-ray
1.60A
)
7OQ8
(X-ray
1.43A
)
7OQ9
(X-ray
1.80A
)
7OQA
(X-ray
1.80A
)
7OQG
(X-ray
1.50A
)
7OQJ
(X-ray
1.40A
)
7OQS
(X-ray
1.34A
)
7OQU
(X-ray
1.40A
)
7OQW
(X-ray
1.90A
)
7OR3
(X-ray
1.80A
)
7OR5
(X-ray
1.80A
)
7OR7
(X-ray
1.80A
)
7OR8
(X-ray
1.80A
)
7ORG
(X-ray
1.80A
)
7ORH
(X-ray
1.80A
)
7ORS
(X-ray
1.80A
)
7ORT
(X-ray
2.33A
)
7QIK
(X-ray
2.01A
)
7QIP
(X-ray
2.65A
)
DBSNP
rs11542705
Subcellular location [CC]
Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
Mouse PG classification
NA
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