| Gene Information | |
|---|---|
| Gene Name | SRD5A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 318 |
| Protein Names | Polyprenol reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 2-like) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3) |
| Target Name | 3-oxo-5-alpha-steroid 4-dehydrogenase |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000128039 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H8P0 |
| Gene Card | SRD5A3 |
| Uniprot ID | Q9H8P0 |
| Pfam | PF02544 |
| In ASD | no |
| Allosteric Prediction | no (-0.799657308) |
| Ortholog in Animals | Alpaca_ SRD5A3 ( ortholog_one2one ) Dog_ SRD5A3 ( ortholog_one2one ) GuineaPig_ SRD5A3 ( ortholog_one2one ) Macaque_ SRD5A3 ( ortholog_one2one ) Mouse_ Srd5a3 ( ortholog_one2one ) Rat_ Srd5a3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in preadipocytes (at protein level) (PubMed:26855069). Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs. {ECO:0000269|PubMed:17986282, ECO:0000269|PubMed:26855069}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000305|PubMed:20637498}; Multi-pass membrane protein {ECO:0000305|PubMed:20637498}. |
| Mouse PG classification | LPG |
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