Gene Information
Gene NameRED1
OrganismHomo sapiens (Human)
Gene Length741
Protein NamesDouble-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP78563
Gene CardADARB1
Uniprot IDP78563
PfamPF02137; PF00035
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityHighly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:9149227}.;
[Isoform 5]: Highly expressed in hippocampus and colon. Expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen. {ECO:0000269|PubMed:19156214}.
Pharmacological Animal Models0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ZY7  (X-ray  1.70A  )  5ED1  (X-ray  2.77A  )  5ED2  (X-ray  2.95A  )  5HP2  (X-ray  2.98A  )  5HP3  (X-ray  3.09A  )  6D06  (X-ray  2.55A  )  6VFF  (X-ray  2.80A  )  7KFN  (X-ray  2.50A  ) 
DBSNP rs199697177 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:32220291}. Nucleus, nucleolus {ECO:0000269|PubMed:32220291}. Note=Shuttles between nucleoli and the nucleoplasm. {ECO:0000305|PubMed:32220291}.;
[Isoform 1]: Nucleus {ECO:0000269|PubMed:32220291}. Nucleus, nucleolus {ECO:0000269|PubMed:32220291}.;
[Isoform 2]: Nucleus {ECO:0000269|PubMed:32220291}. Nucleus, nucleolus {ECO:0000269|PubMed:32220291}.
Mouse PG classificationNA
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