Gene Information
Gene NameMARK4
OrganismHomo sapiens (Human)
Gene Length752
Protein NamesMAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Target Namemap/microtubule affinity-regulating kinase 4
Target TypeNA
Gene Age454 ( ENSG00000007047 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ96L34
Gene CardMARK4
Uniprot IDQ96L34
PfamPF02149; PF00069; PF00627
In ASDno
Allosteric Predictionyes (0.106303593)
Ortholog in AnimalsAlpaca_ MARK4 ( ortholog_one2one )
Dog_ MARK4 ( ortholog_one2one )
GuineaPig_ MARK4 ( ortholog_one2one )
Macaque_ MARK4 ( ortholog_one2one )
Mouse_ Mark4 ( ortholog_one2one )
Pig_ MARK4 ( ortholog_one2one )
Rat_ Mark4 ( ortholog_one2one )
OhnologsMARK2, MARK3
ParalogsMARK2, MARK1, MARK3
TissueNA
Tissue SpecificityUbiquitous. Isoform 2 is brain-specific (PubMed:11326310). Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945). {ECO:0000269|PubMed:11326310, ECO:0000269|PubMed:14594945}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5ES1  (X-ray  2.80A  ) 
DBSNP rs35070611  rs780763668 
Subcellular location [CC]Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14594945}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:14594945}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23400999}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23400999}. Cytoplasm {ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus. {ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:23666762}.
Mouse PG classificationNA
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