| Gene Information | |
|---|---|
| Gene Name | HKDC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 917 |
| Protein Names | Hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000156510 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q2TB90 |
| Gene Card | HKDC1 |
| Uniprot ID | Q2TB90 |
| Pfam | PF00349; PF03727 |
| In ASD | no |
| Allosteric Prediction | yes (0.489870824) |
| Ortholog in Animals | Alpaca_ HKDC1 ( ortholog_one2one ) Dog_ HKDC1 ( ortholog_one2one ) GuineaPig_ HKDC1 ( ortholog_one2one ) Macaque_ HKDC1 ( ortholog_one2one ) Mouse_ Hkdc1 ( ortholog_one2one ) Pig_ HKDC1 ( ortholog_one2one ) Rat_ AABR07045032.1 ( ortholog_one2one ) Rabbit_ HKDC1 ( ortholog_one2one ) |
| Ohnologs | GCK, HK2, HK3 |
| Paralogs | HK1, HK2, HK3, GCK |
| Tissue | duodenum, small.intestine, pineal.gland, small.intestine.Peyers.patch |
| Tissue Specificity | Widely expressed (PubMed:27459389, PubMed:29401404). Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein level) (PubMed:29401404). Present at moderate level in the thyroid follicular epithelium (at protein level) (PubMed:29401404). {ECO:0000269|PubMed:27459389, ECO:0000269|PubMed:29401404}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10823320 rs142379141 rs874556 rs7899445 rs1111335 rs906219 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:30085091}. Mitochondrion membrane {ECO:0000305|PubMed:30517626}; Peripheral membrane protein {ECO:0000305}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q91W97}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion. {ECO:0000305|PubMed:30517626}. |
| Mouse PG classification | NA |
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