| Gene Information | |
|---|---|
| Gene Name | RDH8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 311 |
| Protein Names | Retinol dehydrogenase 8 (EC 1.1.1.300) (Photoreceptor outer segment all-trans retinol dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 2) |
| Target Name | retinol dehydrogenase 8 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000080511 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9NYR8 |
| Gene Card | RDH8 |
| Uniprot ID | Q9NYR8 |
| Pfam | PF00106 |
| In ASD | no |
| Allosteric Prediction | no (-0.626798676) |
| Ortholog in Animals | Alpaca_ RDH8 ( ortholog_one2one ) Dog_ RDH8 ( ortholog_one2one ) GuineaPig_ RDH8 ( ortholog_one2one ) Macaque_ RDH8 ( ortholog_one2one ) Mouse_ Rdh8 ( ortholog_one2one ) Pig_ RDH8 ( ortholog_one2one ) Rat_ Rdh8 ( ortholog_one2one ) Rabbit_ RDH8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DHRS7C, DHRS7, HSD11B1, CBR3, HSDL2, DHRS7B, DHRS2, HSD11B1L, DHRS4L2, DHRS4, DHRS11, CBR1, DHRS1 |
| Tissue | NA |
| Tissue Specificity | Detected in photoreceptor outer segments in the retina (at protein level). {ECO:0000269|PubMed:10753906}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1122206 rs1644731 |
| Subcellular location [CC] | Membrane {ECO:0000305|PubMed:10753906}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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