| Gene Information | |
|---|---|
| Gene Name | RD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 195 |
| Protein Names | Protein RD3 (Retinal degeneration protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000198570 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z3Z2 |
| Gene Card | RD3 |
| Uniprot ID | Q7Z3Z2 |
| Pfam | PF14473 |
| In ASD | no |
| Allosteric Prediction | no (-1.072800369) |
| Ortholog in Animals | Alpaca_ RD3 ( ortholog_one2one ) Dog_ RD3 ( ortholog_one2one ) GuineaPig_ RD3 ( ortholog_one2one ) Macaque_ RD3 ( ortholog_one2one ) Mouse_ Rd3 ( ortholog_one2one ) Pig_ RD3 ( ortholog_one2one ) Rat_ Rd3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RD3L |
| Tissue | pineal.gland |
| Tissue Specificity | Expressed in retina (PubMed:12914764). Widely expressed (at protein level) (PubMed:29030614). In the retina the strongest immunoreactivity is detected in the inner half of the cytoplasmic portion of the photoreceptor layer, where rods and cones are found, and the external half of the outer plexiform layer (at protein level) (PubMed:29030614). {ECO:0000269|PubMed:12914764, ECO:0000269|PubMed:29030614}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6DRF (NMR - ) |
| DBSNP | rs35649846 rs34422496 rs530024772 rs34049451 rs767481165 rs144697496 rs766015590 rs74782684 rs143207434 |
| Subcellular location [CC] | Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q8BRE0}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8BRE0}. Endosome {ECO:0000250|UniProtKB:Q8BRE0}. Nucleus {ECO:0000269|PubMed:26100624, ECO:0000269|PubMed:29030614}. Cytoplasm {ECO:0000269|PubMed:26100624, ECO:0000269|PubMed:29030614}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:29030614}. Note=Colocalizes with GUCY2E and GUCY2F in rods and cones photoreceptors. Colocalizes with GUK1 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer (By similarity). Strong dot-like perinuclear staining in the epithelial cells (PubMed:29030614). {ECO:0000250|UniProtKB:Q8BRE0, ECO:0000269|PubMed:29030614}. |
| Mouse PG classification | HPG |
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