| Gene Information | |
|---|---|
| Gene Name | PLXNB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2135 |
| Protein Names | Plexin-B1 (Semaphorin receptor SEP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000164050 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43157 |
| Gene Card | PLXNB1 |
| Uniprot ID | O43157 |
| Pfam | PF08337; PF20170; PF01437; PF01403; PF01833; PF18020; PF17960 |
| In ASD | yes |
| Allosteric Prediction | yes (0.001567912) |
| Ortholog in Animals | Alpaca_ PLXNB1 ( ortholog_one2one ) Dog_ PLXNB1 ( ortholog_one2one ) GuineaPig_ PLXNB1 ( ortholog_one2one ) Macaque_ PLXNB1 ( ortholog_one2one ) Mouse_ Plxnb1 ( ortholog_one2one ) Pig_ PLXNB1 ( ortholog_one2one ) Rat_ Plxnb1 ( ortholog_one2one ) Rabbit_ PLXNB1 ( ortholog_one2one ) |
| Ohnologs | PLXNA3, PLXNB2, PLXNB3, PLXNA4, PLXND1, PLXNA2, PLXNA1 |
| Paralogs | PLXNA3, PLXNA2, PLXNA1, PLXNA4, PLXNB3, PLXNB2, PLXNC1, PLXND1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. {ECO:0000269|PubMed:8570614}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001759(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2JPH (NMR - ) 2OS6 (NMR - ) 2R2O (X-ray 2.00A ) 2REX (X-ray 2.30A ) 3HM6 (X-ray 2.40A ) 3OL2 (X-ray 2.99A ) 3SU8 (X-ray 3.20A ) 3SUA (X-ray 4.39A ) 5B4W (X-ray 2.60A ) 7VF3 (X-ray 2.29A ) 7VG7 (X-ray 2.50A ) |
| DBSNP | rs34050056 rs35592743 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12533544}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:10520995}.; [Isoform 3]: Secreted {ECO:0000269|PubMed:10520995}. |
| Mouse PG classification | NA |
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