| Gene Information | |
|---|---|
| Gene Name | CLDN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 211 |
| Protein Names | Claudin-1 (Senescence-associated epithelial membrane protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000163347 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95832 |
| Gene Card | CLDN1 |
| Uniprot ID | O95832 |
| Pfam | PF00822 |
| In ASD | no |
| Allosteric Prediction | no (-0.471057708) |
| Ortholog in Animals | Alpaca_ CLDN1 ( ortholog_one2one ) Dog_ CLDN1 ( ortholog_one2one ) GuineaPig_ CLDN1 ( ortholog_one2one ) Macaque_ CLDN1 ( ortholog_one2one ) Mouse_ Cldn1 ( ortholog_one2one ) Pig_ CLDN1 ( ortholog_one2one ) Rat_ Cldn1 ( ortholog_one2one ) Rabbit_ CLDN1 ( ortholog_one2one ) |
| Ohnologs | CLDN15, CLDN10, CLDN8, CLDN6, CLDN9, CLDN18, CLDN19 |
| Paralogs | CLDN5, CLDN8, CLDN3, CLDN20, CLDN11, CLDN14, CLDN18, CLDN7, CLDN10, CLDN9, CLDN17, CLDN24, CLDN22, CLDN23, CLDN4, CLDN15, CLDN19, CLDN34, CLDN2, CLDN25, CLDN16, CLDN6 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. {ECO:0000269|PubMed:9931503}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:23407391}. Cell membrane {ECO:0000269|PubMed:23704991}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:20375010}. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000269|PubMed:20375010}. |
| Mouse PG classification | HPG |
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