| Gene Information | |
|---|---|
| Gene Name | RCK |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P26196 |
| Gene Card | DDX6 |
| Uniprot ID | P26196 |
| Pfam | PF00270; PF00271 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in most tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.040449(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1VEC (X-ray 2.01A ) 2WAX (X-ray 2.30A ) 2WAY (X-ray 2.30A ) 4CRW (X-ray 1.75A ) 4CT4 (X-ray 2.30A ) 4CT5 (X-ray 3.00A ) 5ANR (X-ray 2.10A ) 6F9S (X-ray 3.03A ) 6S8S (X-ray 2.21A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16699599, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:25995375, ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:31422817, ECO:0000269|PubMed:32354837}. Cytoplasm {ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:28216671}. Nucleus {ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:28216671}. Note=Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:28216671). Upon cellular stress, relocalizes to stress granules (PubMed:26184334). {ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:28216671}. |
| Mouse PG classification | NA |
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