| Gene Information | |
|---|---|
| Gene Name | RNF128 |
| Organism | Homo sapiens (Human) |
| Gene Length | 428 |
| Protein Names | E3 ubiquitin-protein ligase RNF128 (EC 2.3.2.27) (Gene related to anergy in lymphocytes protein) (GRAIL) (RING finger protein 128) (RING-type E3 ubiquitin transferase RNF128) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000133135 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TEB7 |
| Gene Card | RNF128 |
| Uniprot ID | Q8TEB7 |
| Pfam | PF02225; PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.756453611) |
| Ortholog in Animals | Alpaca_ RNF128 ( ortholog_one2one ) Dog_ RNF128 ( ortholog_one2one ) GuineaPig_ RNF128 ( ortholog_one2one ) Macaque_ RNF128 ( ortholog_one2one ) Mouse_ Rnf128 ( ortholog_one2one ) Pig_ RNF128 ( ortholog_one2one ) Rat_ Rnf128 ( ortholog_one2one ) Rabbit_ RNF128 ( ortholog_one2one ) |
| Ohnologs | RNF130, RNF149, RNF150 |
| Paralogs | RNF133, RNF149, ZNRF4, RNF130, RNF150, RNF215, RNF167, RNF13, RNF148 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ICU (X-ray 2.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endomembrane system {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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